There is no other culpable than Cucumovirus, which can be identified if looking to it you are able to diferenciate a non-enveloped, spherical virion of about 29 nanometers in diameter, which has a T=3 icosahedral symmetry composed of 180 coat proteins: 12 pentamers and 20 hexamers.
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| Image 2.1. Picture about the real morfology of CMV |
How this murderer is formed of?
It is not an easy question, and there must have being other researchs before answering this issue. His structure is formed of a segmented tripartite linear RNA composed of RNA1, RNA2 and RNA3. Each genomic segment is 3' tRNA-like structure and a 5' cap.
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| Image 2.2. Position of dierent RNA that compose the segmented tripartite linear virus RNA |
This Cucumovirus expresses himself by using the RNA as a messager RNAs. Then, RNA1 and RNA2 encode proteins 1a and 2a, involved in the genome replication and internal transcription of sgRNA4 from the negative copy of RNA3. HRNA3 is translated into a movement protein, while sgRNA4 it translates to a capsid one. Apart from this, ORF2b, present at RNA2, encodes a viral supressor of RNA silencing.
How does it commit the crimes?
When the expression is done, virus expresses the protein 1st and 2nd to produce replication proteins, as I have mentioned before, on the viral factory and after it transcribes/replicates providing new ssRNA genomic (new viruses).
Everithing continues translating RNA4 that produces the capsid that envolves the ssRNA genome, and assemblying this virus particles.
Finally, it is the turn of the viral movement protein, that triggers the information of tubular structures that mediate viron cell-to-cell transfer via a tubule-guided mechanism.
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| Image 2.3. Picture of diferent viral factories for viruses |
Finally, it is the turn of the viral movement protein, that triggers the information of tubular structures that mediate viron cell-to-cell transfer via a tubule-guided mechanism.
